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KMID : 1190620060020020057
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Journal of the Korean Wound Care Society
2006 Volume.2 No. 2 p.57 ~ p.63
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New Protein Repair System Using Fibroblast-Hyaluronic Acid Mixture
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Park Doug-John
Han Seung-Kyu
Lee Byung-Il
Kim Woo-Kyung
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Abstract
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This study was undertaken to evaluate the feasibility of Restylane, which is a modified hyaluronic acid, combined with cultured human dermal fibroblasts, to enhance the longevity of injected implants. The effect of adding fibroblast was determined by evaluating weight change of the cell-Restylane mixture, which was injected in nude mice. Macroscopic and microscopic changes were also investigated. The mean weight of the control group nodules decreased throughout the examination period. On the other hand, the mean weight of the test group nodules decreased only over the first 2 weeks. Beyond 2 weeks, there was no further significant weight change. Histological examinations of the control group exhibited negative immunohistochemical staining for human collagen at each examination period. The test group exhibited positive staining after 2 weeks, indicating the presence of human collagen. These results indicate that Restylane mixed with cultured human dermal fibroblasts maybe successfully injected as living grafts for long-term retention of implants. (J Korean Wound Care Soc 2006;2:57-63)
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KEYWORD
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Hyaluronic acid, Fibroblast
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